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心血管疾病生物学组

 

朱洪新

博士, 交大副研究员, 研究组长, 博导
学    士 (1991-1996) 苏州大学医学院
硕    士 (1996-1999) 同济大学医学院
博    士 (1999-2002) 复旦大学医学院
博士后 (2002-2008) 美国西南医学中心
Email: hxzhu@sjtu.edu.cn

 

个人介绍:  

   目前承担国家重大科学研究计划项目分课题、国家自然科学基金项目。

 

研究方向:

   心肌肥厚与心力衰竭的病理新机制,心肌细胞自体吞噬的信号调控,病毒性心肌炎的分子机制。

 

代表性论文:

1.Zi Z, Song Z, Zhang S, Ye Y, Li C, Xu M, Zou Y, He L, Zhu H*. Rubicon Deficiency Enhances Cardiac Autophagy and Protects Mice From Lipopolysaccharide-induced Lethality and Reduction in Stroke Volume. J Cardiovasc Pharmacol. 2015;65:252-61.
 
2.Zhu H*, He L. Beclin 1 biology and its role in heart disease. Curr Cardiol Rev. 2014 Nov 6. [Epub ahead of print]
 

3.Zhu H*, He L. Autophagy: a potential therapeutic target in cardiac lipotoxicity赟 International Journal of Clinical Therapeutics and Diagnosis (IJCTD) 2014;2:402.

 

4.Zhu H*, He L. UVRAG: A multifunctional protein with essential roles in the heart. J Cardiol Curr Res. 2014;1:00003

 

 5.Song Z, An L, Ye Y, Wu J, Zou Y, He L, Zhu H*. Essential Role for UVRAG in Autophagy and Maintenance of Cardiac Function. Cardiovasc Res. 2014;101:48-56.

 

6.Zhu J, Feng X, Lou J, Li W, Li S, Zhu H, Yang L, Zhang A, He L, Li C. Accurate quantification of microRNA via single strand displacement reaction on DNA origami motif. PLoS One. 2013;8:e69856.

 

7.An L,Zhao X, Wu J, Jia J, Zou Y, Guo X, He L, Zhu H*. Involvement of autophagy in cardiac remodeling in transgenic mice with cardiac specific over-expression of human programmed cell death 5. PLoS One 2012;7:e30097.

 

8.Zhu H, Rothermel BA, Hill JA*. Autophagy in load-induced heart disease. Methods in Enzymology. 2009; 453:343-63.

 

9.Tannous P, Zhu H, Johnstone JL, Shelton JM, Soorrappan R, Benjamin IJ, Gerard RD, Burns DK, Levine B, Rothermel BA, Hill JA*. Autophagy is an adaptive response in desmin-related cardiomyopathy. PNAS. 2008; 105: 9745-50.

 

10.Tannous P, Zhu H, Johnstone JL, Shelton JM., Rothermel BA, Hill JA*. Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation. 2008; 117:3070-8.

 

11.Zhu H, Tannous P, Johnstone JL, Kong Y, Shelton JM, Vien Le, Richardson JA, Levine B, Rothermel BA, Hill JA*. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007; 117(7): 1782-93

 

12.Caprioli A, Zhu H, Sato TN*. CRBP-III:lacZ expression pattern reveals a novel heterogeneity of vascular endothelial cells.Genesis. 2004;40:139-45.

 

#并列第一作者 *通讯作者
 

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