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疾病遗传学组

 

贺 林

博士, 交大教授, 院长, 博导
 

个人介绍:

   遗传生物学家,中国科学院院士,发展中国家科学院院士,“长江学者”特聘教授,国家杰青。上海交通大学教授,Bio-X研究院院长,上海交通大学学术委员会副主任;复旦大学教授、生物医学研究院院长;中国科学院研究员,营养所课题负责人。两任国家973计划首席科学家,国家863计划专家,国家自然科学基金委员会评委,国务院学位评定委员会成员。发表SCI论文300多篇。目前被聘为Biological Experiment and Medicine等副主编,及Psychiatric Genetics, Human Genetics等十多种科学杂志的编委。

 

研究方向:

   疾病与健康(主要集中在单基因病和精神疾病为主的多基因病),营养与健康,转化医学,药物基因组学,DNA计算与技术等。

 

代表性论文:

1.Shi Y#*, Li Z#, Xu Q#, ……, He L*. Common Variants on 8p12 and 1q24.2 Confer Risk of Schizophrenia. Nat Genet. 2011;43(12):1224-7.


2.Chen P#, Pan D#, Fan C, Chen J, Huang K, Wang D, Zhang H, Li Y, Feng G, Liang P, He L, Shi Y *. Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nat Nanotechnol. 2011;6(10):639-44.


3.Li R#, Fan W#, Tian G#, Zhu H#, He L#, Cai J#, ……, Wang J*. The sequence and de novo assembly of the giant pandagenome. Nature. 2010; 463(7279):311-7.


4.Gao B#, Hu J#, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L*, Cheah KS, Chan D. A mutation in Ihh that causes digit abnormalities alters its signaling capacity and range. Nature. 2009; 458(7242):1196-200.


5.O'Donovan MC, ……, He L, ……, Owen MJ. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet. 2008;40(9):1053-1055.


6.St Clair D, Xu M, Wang P, Yu Y, Fang Y, Zhang F, Zheng X, Gu N, Feng G, Sham P*,  He L*. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA. 2005; 294(5):557-62.


7.Gao B, Guo J, She C, Shu A, Yang M, Tan Z, Yang X, Guo S, Feng G, He L*. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nat Genet. 2001; 28(4):386-8.

#并列第一作者 *通讯作者

 

 

周代占

博士, 交大助理研究员
学    士 (2001-2005) 河南大学
博    士 (2006-2011)中国科学院上海生命科学研究院
博士后 (2012-2013) 上海交通大学
Email: zhoudaizhan@sjtu.edu.cn

 个人介绍:

      目前主持国家自然科学青年基金项目、中国博士后一等资助项目和中国博士后特等资助项目。发表SCI论文40余篇,总计被引用400余次,参与编撰学术专著2部。 

 

研究方向

        运用先进的遗传学研究技术(二代测序、基因芯片)及生物信息学方法对精神分裂症、糖尿病、慢性胰腺炎、食管癌、肝癌等疾病进行遗传学(生殖系突变、体细胞突变、遗传突变、拷贝数变异、RNA表达及基因融合)和表观遗传学(DNA甲基化、羟甲基化)的研究。

 
代表性论文:
1.Peng An, Hao Wang, Qian Wu, Xin Guo, Aimin Wu , Zhou Zhang , Di Zhang, Xiaochen Xu , Qianyun Mao , Xiaoyun Shen , Lihong Zhang , ZhiqiXiong , Lin He, Yun Liu, Junxia Min*, Daizhan Zhou*, and Fudi Wang*. Elevated serum transaminase activities were associated with increased serum levels of iron regulatory hormone hepcidin and hyperferritinemia risk. Sci Rep, 2015. (Accept)
 
2.Zhang, H., X. Weng, J. Ye, L. He, D. Zhou*, and Y. Liu*, Promoter hypermethylation of TERT is associated with hepatocellular carcinoma in the Han Chinese population. Clinics and Research in Hepatology and Gastroenterology. 2015.
 
3.Liu, Y., L. Cao, Z. Li, D. Zhou#, W. Liu, Q. Shen, Y. Wu, D. Zhang, X. Hu, T. Wang, J. Ye, X. Weng, H. Zhang, D. Zhang, Z. Zhang, F. Liu, L. He, and Y. Shi, A genome-wide association study identifies a locus on TERT for mean telomere length in Han Chinese. PLoS One. 9(1): p. e85043. 2014.
 
4.Feng, L., D. Zhou#, Z. Zhang, Y. Liu, and Y. Yang, Exome sequencing identifies a de novo mutation in HDAC8 associated with Cornelia de Lange syndrome. J Hum Genet. 2014.
 
5.Weng, X., D. Zhou#, F. Liu, H. Zhang, J. Ye, Z. Zhang, D. Zhang, Y. Wang, L. Tao, L. Cao, M. Kan, T. Wang, G. Feng, X. Qin, J. Sun, L. He, and Y. Liu, DNA methylation profiling in the thalamus and hippocampus of postnatal malnourished mice, including effects related to long-term potentiation. BMC Neurosci. 15: p. 31. 2014
 
6.Liu, Y., D. Zhou#, Z. Zhang, Y. Song, D. Zhang, T. Zhao, Z. Chen, Y. Sun, D. Zhang, Y. Yang, Q. Xing, X. Zhao, H. Xu, and L. He, Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population. J Lipid Res. 52(2): p. 354-360. 2011.
 
7.Liu, Y., D.Z. Zhou, D#. Zhang, Z. Chen, T. Zhao, Z. Zhang, M. Ning, X. Hu, Y.F. Yang, Z.F. Zhang, L. Yu, L. He, and H. Xu, Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China. Diabetologia. 52(7): p. 1315-1321. 2009.
 

#并列第一作者 *通讯作者

 

 

 

李  胜

博士, 交大专职科研
学    士 (1986-1991) 复旦大学
硕    士 (1993-1996)中国科学院上海药物研究所
博    士 (1996-1999) 中国科学院上海神经科学研究所
博士后 (1999-2004) 美国密西根大学
Email: nutrigenomics@hotmail.com

 

个人介绍:

     以往工作中通过遗传学和动物模型等手段,进行了精神分裂症、双相情感障碍、脑卒中、老年痴呆症、肿瘤及多个单基因病等疾病的遗传学和功能学研究以及临床应用和个体化医药研究。发表学术论文和综述论著40余篇。

 

研究方向

       结合基础和临床医学,研究营养代谢,膳食和生活方式等对疾病预防的作用;同时结合个性化基因差异,为慢性营养疾病提供个体化医疗寻找可行途径。

 
代表性论文:

1.# C Ning M, Zhang Z, Chen Z, Zhao T, Zhang D, Zhou D, Li W, Liu Y, Yang Y, Li S*,He L*. Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. Age Ageing. 2011 Jan;40(1):125-8.

 

2.Ning M, Yang YF, Zhang Z, Chen Z, Zhao T, Zhang D, Zhou DZ, Xu J, Liu Z, Wang YB, Liu Y, Zhao XZ, Li WD, Li S* and He L*. Amyloid-related genes SORL1 and ACE are genetically associated with risk for late-onset Alzheimer disease in the Chinese population. Alzheimer Disease & Associated Disorders. 2010 Jul 9.

 

3.Wang Y, Yu L, Zhao T, Xu J, Liu Z, Liu Y, Feng G, He L*, Li S*. No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population. Psychiatry Res. 2009; 169(2):167-8.

 

4.Sun Y#, Huang Y#, Chen X, Liu Y, Lu X, Shi Y, Tang W, Yang J, Chen W, Zhao X, Gao L, Li S*, Feng G, He L*. Association between the PDE4D gene and ischaemic stroke in the Chinese Han population. Clin Sci (Lond). 2009; 117(7):265-72. 

 

5.Xu M*, Li S, Xing Q, Gao R, Feng G, Lin Z, St Clair D, He L*. Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study. Eur J Hum Genet. 2010.

 

6.Swartz BE, Li S, Bespalova I, Burmeister M, Dulaney E, Robinson FR, Leigh RJ*. Pathogenesis of clinical signs in recessive ataxia with saccadic intrusions. Annals of Neurology. 2003; 54(6):824-828.

 

#并列第一作者 *通讯作者

 

 

 

蔡  雷

博士, 交大助理研究员
学    士 (1995-1999) 南京师范大学
硕    士 (1999-2002) 复旦大学生科院
博    士 (2002-2005) 复旦大学遗传所
讲    师 (2005-2006) 复旦大学医学院
Research fellow (2007-2008) 哈佛公共卫生学院
Email: lcai@sjtu.edu.cn

 

个人介绍:

     上海交通大学BIO-X研究院伦理委员会秘书。南京师范大学学士,复旦大学博士。复旦上海医学院讲师,哈佛公共卫生学院Research Fellow。主持了国家自然科学基金,教育部“留学回国人员”科研启动基金,校青年科学基金。

 

研究方向

        现主要研究精神性疾病与炎症的关系。利用群体遗传学方法研究发现致病的遗传等因素,并用分子生物学,蛋白质组学等多种方法验证有关群体遗传的研究结果。

 
代表性论文:

 

1.Lei Cai*, Shao-Li Deng, Li Liang, Hui Pan, Jia Zhou, Mei-Yan Wang, Jun Yue, Chun-Ling Wan, Guang He, Lin He. Identification of genetic associations of SP110/MYBBP1A/RELA with pulmonary tuberculosis in the Chinese Han population (2013). Human Genetics. 132:265-273.

 

2.Lei Cai*, Wei Huang, Kuo-Chen Chou. Prostate cancer with variants in CYP17 and UGT2B17 genes: A meta-analysis (2012). Protein & Peptide Letters.19: 62-69.

 

3.Lei Cai*, Ying Wang, Jing-Fang Wang, Kuo-Chen Chou. Identification of proteins interacting with human SP110 during the process of viral infections (2011). Medicinal Chemistry. 7:121-126.

 

4.Lei Cai*, Hui Pan, Krzysztof Trzciński, Claudette M. Thompson, Qiang Wu and Igor Kramnik (2010). MYBBP1A: a new Ipr1's binding protein in mice. Molecular Biology Reports. 37: 3863-3868.

 

5.Lei Cai, Dongqing Zhang, Yeqing Shi, MK Oaks, Lishan Chen, Jianzhong Jin, Jie Qian, Fang Du, Ningli Li, Xinghai Han and Daming Ren (2005). Association of the CTLA-4 Gene with Rheumatoid Arthritis in Chinese Han Population. European Journal of Human Genetics. 13: 823-828.

 

6.Lei Cai, Guomei Tang, Lishan Chen, Bosheng Zhang, Sanduo Jiang and Daming Ren (2005). Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer’s disease patients. NeuroReport. 16: 1023-1026.

 
 

#并列第一作者 *通讯作者

 

 

 

 

余  涛

博士, 交大助理研究员
学    士 (1997-2003) 泸州医学院/四川大学
硕    士 (2003-2006) 四川大学
博    士 (2006-2010) 四川大学
博士后 (2010-2013) 上海交通大学
博士后 (2013-2014) 伦敦国王大学
Email: yutao03d@gmail.com

 

个人介绍:

     2013年作为上海交通大学助理研究员加入Bio-X研究院。四川大学精神病学与精神卫生专业医学博士,上海交通大学博士后。目前作为科研骨干参与国家973项目、国家自然科学基金项目的研究工作。

 

研究方向

        精神疾病的影像遗传学,神经认知功能,以及精神疾病的分子诊断与个体化治疗。

 
代表性论文:

 

 

1.Yuan A, Li W, Yu T, Zhang C, Wang D, Liu D, Xu Y, Li H, Yu S. SOX10 rs139883 Polymorphism Is Associated with the Age of Onset in Schizophrenia. J Mol Neurosci. 2013; 50(2):333-8.

 

2.Wei Z, Wang L, Yu T, Wang Y, Sun L, Wang T, Huo R, Li Y, Wu X, Qin S, Xu Y, Feng G, He L, Xing Q. Histamine H4 Receptor (HRH4) Polymorphism: a Potential Predictor of Risperidone Efficacy. Journal of Clinical Psychopharmacology. 2013; 33(2):221-5,

 

3.Yuan, A, Yi Z, Sun J, Du Y, Yu T, Zhang C, Liu Y, Zhou Y, Liu D, Li H, Xu Y, Cheng Z, Li W, Yu S. Effect of SOX10 gene polymorphism on early onset schizophrenia in Chinese Han population. Neurosci Lett. 2012; 521(2):93-97.

 

4.Yuan A, Yi ZH, Wang Q, Sun JH, Li ZQ, Yu T, Fan J, Yu SY. ANK3 as a Risk Gene for Schizophrenia: New Data in Han Chinese and Meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2012; 159B(8):997-1005.

 

5.Huang X, Yu T, Liu B, Li X, Li W, Chen S, Zhao Q, Li X, Yang F, Wang Q, Wang J, Xiao Y, Xu Y, Feng G, Peng Z, He L, He G. Association study of APC polymorphisms with colorectal cancer in Han Chinese. Clinical Biochemistry. 2012; 45(18):1669-72.

 

6.Yu T, Guo M, Garza J, Sun XL, Lu XY. Cognitive and neural correlates of depression-like behaviour in socially defeated mice: an animal model of depression with cognitive dysfunction. Int J Neuropsychopharmacol. 2011; 14(3):303-17.

 

7.Min W, Li T, Ma X, Li Z, Yu T, Gao D, Zhang B, Yun Y, Sun X. Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response. Psychopharmacology. 2009; 205(3):409-17.

 
 

#并列第一作者 *通讯作者

 

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