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骨骼干细胞信号转导研究组

 

李保界

博士, 交大特聘教授, 研究组长, 博导
学    士 (1984-1988) 北京师范大学
硕    士 (1992-1994) Albert Einstein College of Medicine
博    士 (1992-1997) Albert Einstein College of Medicine
博士后 (1997-2001) HHMI, Columbia University
Email: libj@sjtu.edu.cn

 

个人介绍:

  李保界博士,长江学者特聘教授、上海市千人计划特聘教授。上海交通大学Bio-X研究院副院长及干细胞与发育研究中心主任。回国之前,在新加坡Institute of Molecular and Cell Biology担任PI(assistant, associate professor)。主持科技部重大科学研究计划、国家自然科学重点和面上项目等基金。共发表60余篇SCI论文。现为中国老年学学会衰老与抗衰老科学委员会副主任委员以及国际杂志BMC Developmental Biology 副主编。

 

研究方向
  间充质干细胞体内自我更新、分化以及衰老的调控机制;骨骼发育、骨代谢以及骨质疏松症的发病机理;DNA损伤应激发应、衰老以及肿瘤发生。

 

代表性论文:

 

1. Keng Po Lai, Wai Fook Leong, Jenny Fung Ling Chau, Deyong Jia, Li Zeng, Huijuan Liu, Aijun Hao, Lin He, Hongbing Zhang, David Meek, Chakradhar Velagapudi, Samy L. Habib, and Baojie Li* (2010). S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J., 29(17):2994-3006

 

2. Gang Ma, Lili Li, Yuanyu Hu, Bijin Au, Lin He and Baojie Li* (2012).  Atypical Atm-p53 interaction in osteogenesis is mediated by Smad1 signaling. J Mol Cell Biol, 4(2): 118-120.

 

3. Jenny Chau, Yuanyu Hu,  Jianhe Wang, Zhi Liu, Bi Jin Au, Yuji Mishina, Ye-Guang Chen, Christine Biondi, Elizabeth Robertson, Yue-Zheng Du, Dong Xie, Xueying Wang, Qiang Yu, and Baojie Li* (2012).  A crucial role for BMP-Smad1 signaling in the DNA damage response. Nature Communications, 2012 May 15; 3:836.

 

4. Kua HY, Liu H, Leong WF, Li L, Jia D, Ma G, Hu Y, Wang X, Chau JF, Chen YG, Mishina Y, Boast S, Yeh J, Xia L, Chen GQ, He L, Goff SP, and Baojie Li *(2012) c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16(INK4a) expression. Nature Cell Biology. 14(7):727-37

 

5. Huijuan Liu, Deyong Jia, Jenny Chau, Lin He and Baojie Li* (2013). p53 regulates neural stem cell self-renewal and differentiation via BMP-Smad1-Id1 pathway.  Stem Cell Dev. 15;22(6):913-27.

 

6. Hao Jia, Jenny Fang Ling Chau, Qian Cong, and Baojie Li* (2014).  A critical role for p57Kip2 in the DNA damage response.  Oncogene.  2014 Sep 8. doi: 10.1038/onc.2014.287. [Epub ahead of print].

 

7. Bing Qi1 , Qian Cong 2 , Ping Li2, Gang Ma2, Xizhi Guo2, Min Xie3, Michael D. Schneider4, Huijuan Liu2, #, and Baojie Li* (2014) Ablation of Tak1 in monocyte leads to defects in skeletal growth and bone remodeling in mice.  Scientific Reports, Nov 24; 4:7158.

 

8. Xinsen Ruan1,*, Qiao Zuo2,*, Jenny Chua3, Hao Jia1, Jinlin Lin1, Xuechun Xia1, Huijuan Liu1, Samy L. Habib4, Chuangang Fu2, 5, and Baojie Li*.  p53 deficiency-induced Smad1 up-regulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers.  J Mol Cell Biol. 2015 Mar 10. pii: mjv015. [Epub ahead of print]

 

#并列第一作者 *通讯作者

 

 

 

刘慧娟

博士, 交大副研究员, 硕导
学    士 (1996-2000) 陕西师范大学
硕    士 (2003-2006) 河南师范大学
博    士 (2007-2010) 山东大学
博士后 (2010-2012) 上海交通大学
Email: liumiaomiao333@163.com


 

个人介绍:

  刘慧娟博士,目前主持国家自然基金青年项目,作为科研骨干参与国家973项目、国家自然基金重点项目等。

 

研究方向
   间充质干细胞体内自我更新、分化以及衰老的调控机制;DNA损伤应激发应、衰老以及肿瘤发生。

 

代表性论文:

1.Kua HY#, Liu Huijuan#, Leong WF, Li L, Jia D, Ma G, Hu Y, Wang X, Chau JF, Chen YG, Mishina Y, He L, Goff SP, Li B. c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16(INK4a) expression. Nat Cell Biol. 2012;24;14(7):727-37.
 

2.Liu Huijuan, Jia D, Li A, Chau J, He D, Ruan X, Liu F, Li J, He L, Li B. p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1. Stem Cells Dev. 2013;22(6):913-27.

 

3.Liu Huijuan, Li B. p53 control of bone remodeling. J Cell Biochem. 2010;111(3):529-34.

 

4.Liu Huijuan, Jia D, Fu J, Zhao S, He G, Ling EA, Gao J, Hao A. Effects of granulocyte colony-stimulating factor on the proliferation and cell-fate specification of neural stem cells.  Neuroscience. 2009;164(4):1521-30.

 

5.Lai KP, Leong WF, Chau JF, Jia D, Zeng L, Liu Huijuan, He L, Hao A, Zhang H, Meek D, Velagapudi C, Habib SL, Li B. S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J. 2010;29(17):2994-3006.

 

6.Ma G, Li L, Hu Y, Chau JF, Au BJ, Jia D, Liu Huijuan, Yeh J, He L, Hao A, Li B. Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling. J Mol Cell Biol. 2012;4(2):118-20.

 

7.Jia DY#, Liu huijuan#, Wang FW, Liu SM, Ling EA, Liu K, Hao AJ. Folic acid supplementation affects apoptosis and differentiation of embryonic neural stem cells exposed to high glucose. Neurosci Lett. 2008;440(1):27-31.

 

 

#并列第一作者 *通讯作者

 

 

 

夏学春

博士, 交大副研究员, 硕导
学    士 (1991-1995) 武汉大学
硕    士 (1998-2001) 浙江大学
博    士 (2001-2006) 中科院上海生化所
博士后 (2006-2008) 美国德州大学圣安东尼健康中心
博士后 (2008-2011) 弗罗里达大学
Email: xuechun.xia@sjtu.edu.cn


 

 

个人介绍:

  上海交通大学Bio-X研究院副研究员。武汉大学学士,浙江大学硕士,中国科学院上海生物化学与细胞生物学研究所博士,美国德州大学圣安东尼健康中心和弗罗里达大学博士后。

 

研究方向
   骨质疏松的基础及临床前研究。 成体间充质细胞趋成骨细胞的分化特性研究。

 

代表性论文:

1.Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX. Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci U S A. 2012, 109(9): 3359-64.

 

2.Shalhoub V, Shatzen EM, Ward SC, Davis J, Stevens J, Bi V, Renshaw L, Hawkins N, Wang W, Chen C, Tsai MM, Cattley RC, Wronski TJ, Xia X, Li X, Henley C, Eschenberg M, Richards WG. FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality. J Clin Invest. 2012, 122(7): 2543-53.

 

3.Aguirre JI, Akhter MP, Kimmel DB, Pingel J, Xia X, Williams A, Jorgensen M, Edmonds K, Lee JY, Reinhard MK, Battles AH, Kesavalu L, Wronski TJ. Enhanced alveolar bone loss in a model of non-invasive periodontitis in rice rats. Oral Dis. 2012, 18(5): 459-68.

 

4.Halloran BP, Wronski TJ, Herzen DV, Chu V, Xia X, Pingel JE, Smith B. Dietary dried plum increases bone mass in adult and aged mice. Journal of Nutrition, 2010, 140(10): 1781-1787.

 

5.Xia X, Kar R, Gluhak-Heinrich J, Yao W, Lane NE, Bonewald LF, Biswas SK, Lo WK, Jiang JX. Glucocorticoid induced autophagy in osteocytes. Journal of Bone and Mineral Research, 2010, 25(11): 2479–2488.

 

6.Xia X, Batra N, Shi Q, Bonewald LF, Sprague E, Jiang JX. Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3/beta-catenin signaling. Molecular and Cellular Biology, 2010, 30(1): 206-219.

 

7.Xia X, Hou F, Li J, Ke Y, Nie H. Two novel proteins bind specifically to trichosanthin on choriocarcinoma cell membrane. Journal of Biochemistry, 2006, 139: 725-731.

 

8.Xia X, Hou F, Li J, Nie H. Ribosomal protein L10a, a bridge between trichosanthin and the ribosome. Biochemical and Biophysical Research Communications, 2005, 336: 281-286.

 

#并列第一作者 *通讯作者

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