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分子生殖生物学与干细胞生物学研究组

 

吴际
博士, 交大特聘教授, 研究组长, 博导

博    士 (1994-1997) 北京大学
博士后 (1997-1999) 德国格丁根大学、德国灵长中心
Email: jiwu@sjtu.edu.cn   Tel: 34207263

 

个人介绍:

  1999-2004年美国犹他大学Research Fellow、美国天普大学Associate Scientist。入选上海市优秀学科带头人; 成果入选“中国高等学校十大科技进展”; 2003年获“教育部自然科学二等奖”。现为美国RB&E等数家国际杂志编委或客座编辑,Nature Cell Biol等杂志特邀审稿人, 香港研究资助局大学教育资助委员会国际评委,国家自然科学基金委第十三届专家评审组成员,中国生殖生物学会理事。发表论文50余篇。

 

研究方向

   分子生殖生物学与生殖医学;

  干细胞生物学。

 

代表性论文:

1. Zhang Y#.., Yang Z#.., Yang Y#., Wang S#.., Shi L., Xie W., Sun K., Zou K., Wang L., Xiong J., Xiang J, Wu J.* Production of transgenic mice by random recombination of targeted genes in female germline stem cells. Journal of Molecular Cell Biology 2011; 3: 132-141
 

2. Zou K, Hou L., Sun K., Xie W., Wu J.* Improved Efficiency of Female Germline Stem Cell Purification Using Fragilis-Based Magnetic Bead Sorting. Stem Cells and Development; 2011; 20: 2197-2204
 

3. Xiong J#., Wang H#., Guo G., Wang S., He L*., Chen H*., Wu J.*. Male Germ Cell Apoptosis and Epigenetic Histone Modification Induced by Tripterygium wilfordii Hook F. PLoS ONE 2011; 6: e20751
 

4. Zou K, Yuan Z, Yang Z, Luo H, Sun K, Zhou L, Xiang J, Shi L, Yu Q, Zhang Y, Hou R, Wu J.* Production of offspring from a germline stem cell line derived from ovaries. Nature Cell Biology 2009; 11: 631-636 (Table of Contents Cover Story).
 

5. Yuan Z., Hou R., Wu J. * Generation of mice by transplantation of an adult  spermatogonial cell line after cryopreservation. Cell proliferation 2009; 42: 123-131.
 

6. Zhang Y., Wu J. *  Molecular cloning and characterization of a new gene, Oocyte- G1.  J cell Physiol 2009; 218: 75-83 (Cover Story).
 

7. Wu J. *, Zhang Y., Tian G.G., Zou K., Lee C.M., Yu Q., Yuan Z. Short-type PB-cadherin promotes self-renewal of spermatogonial stem cells via multiple signaling pathways. Cell Signal. 2008; 20:1052-1060.
 

#并列第一作者 *通讯作者

 

 

龚小雯

博士, 交大助理研究员

学士(1998-2002)华东理工大学

博士(2003-2010)中科院上海生命科学研究院

助理研究员(2010-2014)中科院上海生命科学研究院营养所

博士后(2015-2017)交大医学院附属国际和平妇幼保健院

Emailgong.xiaowen@gmail.com

 

个人介绍:

        2017年作为上海交通大学助理研究员加入Bio-X研究院。中科院上海生命科学研究院生化细胞所博士,上海交大医学院博士后。目前作为科研骨干参与课题组的研究工作。

 

研究方向

  生殖干细胞的自我更新及分化调控

 

代表性论文:

(1) Yinjuan Wang#, Xiaoyong Li#, Xiaowen Gong, Yongqiang Zhao, and Ji Wu*. Microrna-322 Regulates Self-Renewal of Mouse Spermatogonial Stem Cells through Rassf8. International journal of biological sciences, 15 (2019), 857-69

(2) Jie Wang#;Xiaowen Gong;Geng G.Tian;Changliang Hou;Xiaoqin Zhu;Xiuying Pei;Yanrong Wang;Ji Wu*.Long noncoding RNA growth arrest-specific 5 promotes proliferation and survival of female germline stem cells in vitro. Gene, 2018, 653: 14-21

(3) Xiaowen Gong#, HuiXie#, Xiaoyong Li, Ji Wu and Yi Lin. Bisphenol A induced apoptosis and transcriptome differences of spermatogonial stem cells in vitro. ActaBiochimBiophysSin(Shanghai), 2017, 49(9): 780-7912

(4) Weiyuan Ye#, XiaowenGong#, Jing Xie, Jun Wu, Xuejin Zhang, Qi Ouyang, Xiaolin Zhao, Yufang Shi, Xuejun Zhang*, AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion. Apoptosis, 2010, 15:474-487

(5) XiaohuiRen#, Jingya Zhang , Xiaowen Gong, XinNiu, Xuejin Zhang, Peng Chen, and Xuejun Zhang*. Differentiation of murine embryonic stem cells toward renal lineages by conditioned medium from ureteric bud cells in vitro. ActaBiochimBiophys Sin (Shanghai) 2010, 42, 07: 464–471

(6) Xiaowen Gong#, Weiyuan Ye#, Haibo Zhou, XiaohuiRen, Zhigang Li, Weiyin Zhou, Jun Wu, Yicheng Gong, Qi Ouyang, Xiaolin Zhao, Xuejun Zhang*, RanBPM is an acetylcholinesterase-interacting protein that translocates into the nucleus during apoptosis. ActaBiochimBiophys Sin (Shanghai), 2009, 41: 883-891

(7) Han Yan#,ZhanyunGuo, Xiaowen Gong, Dan Xi,YouminFeng*. A peptide model of insulin folding intermediate with one disulfide. Protein Science. 2003, 12(4): 768–775

 

#并列第一作者 *通讯作者

 

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