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发育功能基因组学组

 

马钢
博士,上海交大副研究员, 研究副组长, 硕导

学士(94-98) 安徽科技学院
硕士(98-01) 长春军需大学
博士(04-07) 上海交通大学
Email: magang@sjtu.edu.cn

 

个人介绍:
          研究方向为器官发育与信号转导,包括骨骼与皮肤的发育与重要信号通路之间的关系,如Hedgehog信号,Wnt信号和BMP信号。迄今发表SCI收录论文23篇(其中第一或者通讯作者8篇),总影响因子140,共计他引300余次,申请专利2项。目前负责两项973计划子课题、国家自然基金项目、上海市自然基金及上海交大晨星学者SMC计划课题等等。作为指导老师带领上海交大iGEM队伍参加国际合成生物学竞赛,连续获得金牌和亚洲区总冠军,最佳模块设计奖及全球最佳16队等奖项。

 

研究方向

1.软骨发育及形态发生的分子机制研究,指再生的研究;

2.皮肤损伤修复及再生研究;

3.合成生物学中特定生物学功能模块的设计与开发。

代表性论文:

1.Xuming Zhu#, Yumei Wu#, Sixia Huang, Yingwei Chen, Yixin Tao, Yushu Wang, Shigang He, Sanbing Shen, Ji Wu, Xizhi Guo, Baojie Li, Lin He* and Gang Ma*. Over-expression of Wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development. Exp Dermatol. 2014 Dec; 23(12):926-8.

 

2.Xuming Zhu, Sixia Huang, Lingling Zhang, Yumei Wu, Yingwei Chen, Yixin Tao, Yushu Wang, Shigang He, Sanbing Shen, Ji Wu, Baojie Li, Xizhi Guo*, Lin He*, Gang Ma*. Constitutive activation of ectodermal β-catenin induces ectopic outgrowths at various positions in mouse embryo and affects abdominal ventral body wall closure. PLoS One. 2014 19;9 (3): e92092.

 

3.Sixia Huang#, Xuming Zhu#, Yanfang Liu, Yixin Tao, Guoyin Feng, Lin He, Xizhi Guo*, Gang Ma*. Wls is Expressed in the Epidermis and Regulates Embryonic Hair Follicle Induction in Mice. PLoS ONE 2012, 7(9): e45904.

 

4.Hui-Yi Kua#, Huijuan Liu#, Wai Fook Leong#, Lili Li, Deyong Jia, Gang Ma, Yuanyu Hu, Xueying Wang, Jenny F. L. Chau, Ye-Guang Chen, Yuji Mishina, Sharon Boast, James Yeh, Li Xia, Guo-Qiang Chen, Lin He, Stephen P. Goff, and Baojie Li. c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16 INK4a expression. Nature Cell Biology. 2012, 7: 727-737

 

5.Gang Ma#, Lili Li#, Yuanyu Hu, Jenny Fung Ling Chau, Bi Jin Au, Deyong Jia, Huijuan Liu, James Yeh, Lin He, Aijun Hao*, and Baojie Li*. Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling. Journal of Molecular Cell Biology. Journal of Molecular Cell Biology 2012; 4(2):118-20.

 

6.Ma G, Yu J, Xiao Y, Chan D, Gao B*, Hu J, He Y, Guo S, Zhou J, Zhang L, Gao L, Zhang W, Kang Y, Cheah KS, Feng G, Guo X, Wang Y, Zhou CZ, He L*. INDIAN HEDGEHOG mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. Cell Research 2011; 21(9):1343-57.

 

7.Gao B#, Hu J#, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L*, Cheah KS, Chan D*. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 2009; 458, 1196-1200.

 

8.Ma G, Xiao Y, He L*. Recent progress in the study of Hedgehog signaling. Journal of Genetics and Genomics 2008; 35(3): 129-137.

 

9.Ma G#, He Z#, Fang W, Tang W, Huang K, Li Z, He G, Xu Y, Feng G, Zheng T, Zhou J, He L*, Shi Y*. The Ser9Gly Polymorphism of the Dopamine D3 Receptor Gene and Risk of Schizophrenia: An Association Study and a large Meta-Analysis. Schizophrenia research 2008; 101:26-35.

 

10.Ma G#, Shi Y#*, Tang W, He Z, Huang K, Li Z, He G, Feng G, Li H, He L*. An association study between the genetic polymorphisms within TBX1 and schizophrenia in the Chinese population. Neurosci Lett 2007; 425(3):146-150.

 

#并列第一作者 *通讯作者

 

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