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个体化医学研究组

 

秦胜营
博士, 交大副教授, 研究组长,  博导

学    士 (1994-1998) 山东师范大学
博    士 (2000-2005) 上海交通大学

访问学者  (2014-2015) 美国哈佛大学及Broad研究所
Email: chinsir@163.com

 

个人介绍:

       现任我国药物基因组学专业委员会副秘书长、常委,亚洲药物基因组研究协会会员,上海市医学遗传学青年委员,国际严重药物不良反应联盟科学管理委员会成员。同时被聘为International Journal of Genetics杂志Editor-in-Chief,American Journal of Life Sciences特别期刊:Pharmacogenomics and personalized medicine的Guest Editor,《世界复合医学》杂志特邀编委,山西国信凯尔医学检验所名誉顾问。发表学术论文60余篇,申请专利18项,已授权6项。国家863重大专项课题、国际严重药物不良反应合作课题、国家新药创制重大专项子课题、国家自然科学基金、上海市重大基础研究计划子课题、上海市自然科学基金等科研项目负责人。曾获国际人类遗传学会议青年研究者奖、上海交大晨星学者SMC优秀青年教师奖、优秀博士后奖励基金一等奖。

 

研究方向

      探索不同个体对药物、环境等各类因子的反应存在差异的分子机制,研究并发现心血管疾病、精神疾病、肿瘤、严重药物不良反应、重大出生缺陷等一系列个体化医学相关分子标记物,研制生物芯片、新一代测序等高通量快速检测技术手段,建立个体化医疗指导体系。

 

代表性论文:
1. Xu Q ,Wu X ,Li M ,Huang H ,Minica C ,Yi Z ,Wang G , Shen L,Xing Q ,Shi Y ,He L  and Qin S *, Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population. The Pharmacogenomics Journal,2015, [Epub ahead of print]

2. Zhao S ,Chen r ,Yu Y ,He L,Liu J-Q , Chen X* and  QinS* , A multifunctional, plug-and-play and lowcost microfluidic connector system based on the standard of electronics, RSC Advances, 2015, 5, 97422 - 97426

3. Ruan Y, Shen L, Zou Y, Qi Z, Yin J, Jiang J, Guo L, He L, Chen Z, Tang Z, Qin S*.Comparative genome analysis of Prevotella intermedia strain isolated from infected root canal reveals features related to pathogenicity and adaptation. BMCGenomics. 2015 ;16(1):122.

4. Zhao B, Qin S#, Teng Z, Chen J, Yu X, GaoY, Shen J, Cui X, Zeng M, Zhang X. Epidemiological study of influenza B in Shanghai during the 2009-2014 seasons: implications for influenza vaccination strategy. Clin Microbiol Infect. 2015. [Epub ahead of print]

5. Jiang J, Zhang X, Huo R, Li X, Yang Y, Gai Z, Xu M, Shen L, Cai L, Wan C, Li B, He L, Qin S*. Association study of UGT1A9 promoter polymorphisms with DILI based on systematically regional variation screen in Chinese population. The Pharmacogenomics Journal. 2014 75.

6. Xiong Y,  Wei Z,  Huo R,  Wu X,  Shen L,  Li Y,  Gong X,  Wu Z,  Feng G,  Li W,  He L,  Xing Q,  Qin S*,  A pharmacogenetic study of risperidone on chemokine (C-C motif) ligand 2 (CCL2) in Chinese Han schizophrenia patients., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2014,51C, pp 153-158.

7. Shi Y, Liu Y, Wei Z, Zhang Y, Zhang L, Jiang S, Xiong Y, Shen L, He L, Xing Q,Qin S *. Hsa-miR-27a is involved in the regulation of CYP3A4 expression in human livers from Chinese Han population. Pharmacogenomics. 2015. [Epub ahead of print]

8. Zhao X#, Qin S#, Shi Y, Zhang A, Zhang J, Bian L, Wan C, Feng G, Gu N, Zhang G, He G*, He L*. Systematic study of association of four GABAergic genes, GAD1, GAD2, GABBR1 and GABRB2, with schizophrenia using a universal DNA microarray. Schizophr Res. 2007; 93:374-384.

9. Qin S#, Zhao X#, Pan Y, Liu J, Feng G, Fu J, Bao J, Zhang Z, He L*. An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. Eur J Hum Genet. 2005; 13(7):807-814.
 
 
 

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