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Cardiobiology

 

Hongxin ZHU

Ph. D., Assistant Research Fellow, Principal Investigator
Email: hxzhu@sjtu.edu.cn

 

INTRODUCTION:

  Dr. Zhu’s research works have been sponsored by 973 Program and NSFC.

 

RESEARCH INTERESTS:

  Novel mechanism of cardiac hypertrophy and heart failure; Signaling of cardiac autophagy; Molecular mechanism of viral myocarditis and cardiomyopathy.

 

REPRESENTATIVE PUBLICATIONS:

1. Zi Z, Song Z, Zhang S, Ye Y, Li C, Xu M, Zou Y, He L, Zhu H*. Rubicon Deficiency Enhances Cardiac Autophagy and Protects Mice From Lipopolysaccharide-induced Lethality and Reduction in Stroke Volume. J Cardiovasc Pharmacol. 2015;65:252-61.

2. Zhu H*, He L. Beclin 1 biology and its role in heart disease. Curr Cardiol Rev. 2014 Nov 6. [Epub ahead of print]

3. Zhu H*, He L. Autophagy: a potential therapeutic target in cardiac lipotoxicity? International Journal of Clinical Therapeutics and Diagnosis (IJCTD) 2014;2:402.

4. Zhu H*, He L. UVRAG: A multifunctional protein with essential roles in the heart. J Cardiol Curr Res. 2014;1:00003

5. Song Z, An L, Ye Y, Wu J, Zou Y, He L, Zhu H*. Essential Role for UVRAG in Autophagy and Maintenance of Cardiac Function. Cardiovasc Res. 2014;101:48-56.

6. Zhu J, Feng X, Lou J, Li W, Li S, Zhu H, Yang L, Zhang A, He L, Li C. Accurate quantification of microRNA via single strand displacement reaction on DNA origami motif. PLoS One. 2013;8:e69856.

7. An L, Zhao X, Wu J, Jia J, Zou Y, Guo X, He L, Zhu H*. Involvement of autophagy in cardiac remodeling in transgenic mice with cardiac specific over-expression of human programmed cell death 5. PLoS One 2012;7:e30097.

8. Zhu H, Rothermel BA, Hill JA*. Autophagy in load-induced heart disease. Methods in Enzymology. 2009; 453:343-63.

9. Tannous P, Zhu H, Johnstone JL, Shelton JM, Soorrappan R, Benjamin IJ, Gerard RD, Burns DK, Levine B, Rothermel BA, Hill JA*. Autophagy is an adaptive response in desmin-related cardiomyopathy. PNAS. 2008; 105: 9745-50.

10. Tannous P, Zhu H, Johnstone JL, Shelton JM., Rothermel BA, Hill JA*. Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation. 2008; 117:3070-8.

11. Zhu H, Tannous P, Johnstone JL, Kong Y, Shelton JM, Vien Le, Richardson JA, Levine B, Rothermel BA, Hill JA*. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007; 117(7): 1782-93

12. Caprioli A, Zhu H, Sato TN*. CRBP-III:lacZ expression pattern reveals a novel heterogeneity of vascular endothelial cells.Genesis. 2004;40:139-45.

# Contributed equally to the paper * Corresponding author

 

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