Home> Research
Diseases Genetics


Lin HE

Ph. D., Professor, Director

Email: helin@bio-x.cn


       Genetic biologist, Fellow of Chinese Academy of Sciences, Fellow of TWAS. Professor and Director of Bio-X Institutes, Shanghai Jiao Tong University. Professor and Director of Institutes of Biomedical Scieces, Fudan University. Professor and PI of Shanghai Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences. Associate editor of “Biological Experiment and Medicine” and editors for more than 10 scientific journals. The chief scientist of the National 973 Program, member of the Expert Steering Committee for the 863 Programs. By now he has published over 300 peer-reviewed papers.


        Molecular mechanisms underlying genetic disorders, including major monogenic and polygenic diseases of which psychiatric disorders are mainly focused on, nutrigenomics, pharmacogenomics, translational medicine, and DNA computing technology, etc


1. Shi Y#*, Li Z#, Xu Q#, ……, He L*. Common Variants on 8p12 and 1q24.2 Confer Risk of Schizophrenia. Nat Genet. 2011;43(12):1224-7.
2. Chen P#, Pan D#, Fan C, Chen J, Huang K, Wang D, Zhang H, Li Y, Feng G, Liang P, He L, Shi Y *. Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nat Nanotechnol. 2011;6(10):639-44.
3. Li R#, Fan W#, Tian G#, Zhu H#, He L#, Cai J#, ……, Wang J*. The sequence and de novo assembly of the giant pandagenome. Nature. 2010; 463(7279):311-7.
4. Gao B#, Hu J#, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L*, Cheah KS, Chan D. A mutation in Ihh that causes digit abnormalities alters its signaling capacity and range. Nature. 2009; 458(7242):1196-200.
5. O'Donovan MC, ……, He L, ……, Owen MJ. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet. 2008;40(9):1053-1055.
6. St Clair D, Xu M, Wang P, Yu Y, Fang Y, Zhang F, Zheng X, Gu N, Feng G, Sham P*,  He L*. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA. 2005; 294(5):557-62.
7. Gao B, Guo J, She C, Shu A, Yang M, Tan Z, Yang X, Guo S, Feng G, He L*. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nat Genet. 2001; 28(4):386-8.

# Contributed equally to the paper * Corresponding author




Daizhan ZHOU

Ph. D., Assistant Research Fellow

Email: zhoudaizhan@sjtu.edu.cn


       Supported by the National Natural Science Foundation of China (31200954, Beijing, PR China) and the China Postdoctoral Science Foundation funded project (2012M510110 and 2013T60440, Beijing, PR China). Dr. Zhou has participated in the compilation of two academic books and published more than 40 SCI papers, which have been cited more than 400 times.


       Using genetic technologies (gene chips and next generation sequencing) and bioinformatic methods to identify the pathogenesis of diabetes, schizophrenia, esophageal squamous cell carcinoma, hepatocellular carcinoma and chronic pancreatitis.


1.Peng An, Hao Wang, Qian Wu, Xin Guo, Aimin Wu , Zhou Zhang , Di Zhang, Xiaochen Xu , Qianyun Mao , Xiaoyun Shen , Lihong Zhang , ZhiqiXiong , Lin He, Yun Liu, Junxia Min*, Daizhan Zhou*, and Fudi Wang*. Elevated serum transaminase activities were associated with increased serum levels of iron regulatory hormone hepcidin and hyperferritinemia risk. Sci Rep, 2015. (Accept)

2.Zhang, H., X. Weng, J. Ye, L. He, D. Zhou*, and Y. Liu*, Promoter hypermethylation of TERT is associated with hepatocellular carcinoma in the Han Chinese population. Clinics and Research in Hepatology and Gastroenterology. 2015.

3.Liu, Y., L. Cao, Z. Li, D. Zhou#, W. Liu, Q. Shen, Y. Wu, D. Zhang, X. Hu, T. Wang, J. Ye, X. Weng, H. Zhang, D. Zhang, Z. Zhang, F. Liu, L. He, and Y. Shi, A genome-wide association study identifies a locus on TERT for mean telomere length in Han Chinese. PLoS One. 9(1): p. e85043. 2014.

4.Feng, L., D. Zhou#, Z. Zhang, Y. Liu, and Y. Yang, Exome sequencing identifies a de novo mutation in HDAC8 associated with Cornelia de Lange syndrome. J Hum Genet. 2014.

5.Weng, X., D. Zhou#, F. Liu, H. Zhang, J. Ye, Z. Zhang, D. Zhang, Y. Wang, L. Tao, L. Cao, M. Kan, T. Wang, G. Feng, X. Qin, J. Sun, L. He, and Y. Liu, DNA methylation profiling in the thalamus and hippocampus of postnatal malnourished mice, including effects related to long-term potentiation. BMC Neurosci. 15: p. 31. 2014

6.Liu, Y., D. Zhou#, Z. Zhang, Y. Song, D. Zhang, T. Zhao, Z. Chen, Y. Sun, D. Zhang, Y. Yang, Q. Xing, X. Zhao, H. Xu, and L. He, Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population. J Lipid Res. 52(2): p. 354-360. 2011.

7.Liu, Y., D.Z. Zhou, D#. Zhang, Z. Chen, T. Zhao, Z. Zhang, M. Ning, X. Hu, Y.F. Yang, Z.F. Zhang, L. Yu, L. He, and H. Xu, Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China. Diabetologia. 52(7): p. 1315-1321. 2009.

# Contributed equally to the paper * Corresponding author 




Sheng LI

Ph. D., Full-time Research Fellow

Email: nutrigenomics@hotmail.com


        By using genetics methods and animal models, Dr. Li focuses on genetics and functional studies of schizophrenia, bipolar disorders, stroke, Alzheimer's diesease, cancer and monogene diseases etc., which research results may be use on clinical application and personal medicine. By now, more than 40 papers and reviewers were published.


        Combined with basic and clinical medicine, disease prevention could be proved by changing nutrition, diet and life styles together with individualized medicine.



1.# C Ning M, Zhang Z, Chen Z, Zhao T, Zhang D, Zhou D, Li W, Liu Y, Yang Y, Li S*,He L*. Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. Age Ageing. 2011 Jan;40(1):125-8.

2.Ning M, Yang YF, Zhang Z, Chen Z, Zhao T, Zhang D, Zhou DZ, Xu J, Liu Z, Wang YB, Liu Y, Zhao XZ, Li WD, Li S* and He L*. Amyloid-related genes SORL1 and ACE are genetically associated with risk for late-onset Alzheimer disease in the Chinese population. Alzheimer Disease & Associated Disorders. 2010 Jul 9.

3.Wang Y, Yu L, Zhao T, Xu J, Liu Z, Liu Y, Feng G, He L*, Li S*. No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population. Psychiatry Res. 2009; 169(2):167-8.

4.Sun Y#, Huang Y#, Chen X, Liu Y, Lu X, Shi Y, Tang W, Yang J, Chen W, Zhao X, Gao L, Li S*, Feng G, He L*. Association between the PDE4D gene and ischaemic stroke in the Chinese Han population. Clin Sci (Lond). 2009; 117(7):265-72. 

5.Xu M*, Li S, Xing Q, Gao R, Feng G, Lin Z, St Clair D, He L*. Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study. Eur J Hum Genet. 2010.

6.Swartz BE, Li S, Bespalova I, Burmeister M, Dulaney E, Robinson FR, Leigh RJ*. Pathogenesis of clinical signs in recessive ataxia with saccadic intrusions. Annals of Neurology. 2003; 54(6):824-828.

# Contributed equally to the paper * Corresponding author 





Ph. D., Assistant Research Fellow

Email: lcai@sjtu.edu.cn


        Secretary of the Bioethics Committee of Bio-X Institutes of Shanghai Jiaotong University. BS-Nanjing Normal University, Ph.D-Fudan University, lecturer-Shanghai Medical College of Fudan University, research fellow-Harvard School of public health. Projects: Chinese National Science Foundation (No. 31101015), the scientific research foundation for the returned overseas, the Chinese Ministry of Education (No. 12Z102050009), and funding for Biomedical Multidisciplinary Research.



        Cross-disorders of psychiatric illness and inflammation,investigation of genetic variants that influence traits related to these disorders with methods from epidemiology and population genetics, validation of these genetic variants with from molecular and cellular biology, and system bioloby.


1.Lei Cai*, Shao-Li Deng, Li Liang, Hui Pan, Jia Zhou, Mei-Yan Wang, Jun Yue, Chun-Ling Wan, Guang He, Lin He. Identification of genetic associations of SP110/MYBBP1A/RELA with pulmonary tuberculosis in the Chinese Han population (2013). Human Genetics. 132:265-273.

2.Lei Cai*, Wei Huang, Kuo-Chen Chou. Prostate cancer with variants in CYP17 and UGT2B17 genes: A meta-analysis (2012). Protein & Peptide Letters.19: 62-69.

3.Lei Cai*, Ying Wang, Jing-Fang Wang, Kuo-Chen Chou. Identification of proteins interacting with human SP110 during the process of viral infections (2011). Medicinal Chemistry. 7:121-126.

4.Lei Cai*, Hui Pan, Krzysztof Trzciński, Claudette M. Thompson, Qiang Wu and Igor Kramnik (2010). MYBBP1A: a new Ipr1's binding protein in mice. Molecular Biology Reports. 37: 3863-3868.

5.Lei Cai, Dongqing Zhang, Yeqing Shi, MK Oaks, Lishan Chen, Jianzhong Jin, Jie Qian, Fang Du, Ningli Li, Xinghai Han and Daming Ren (2005). Association of the CTLA-4 Gene with Rheumatoid Arthritis in Chinese Han Population. European Journal of Human Genetics. 13: 823-828.

6.Lei Cai, Guomei Tang, Lishan Chen, Bosheng Zhang, Sanduo Jiang and Daming Ren (2005). Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer’s disease patients. NeuroReport. 16: 1023-1026.

# Contributed equally to the paper * Corresponding author 




Tao YU

Ph. D., Assistant Research Fellow

Email: yutao03d@gmail.com


        Dr. Tao Yu joined the Bio-X Institutes at Shanghai Jiao Tong University as a Research Assistant Professor in 2013. He received his Ph.D. in Psychiatry at Sichuan University in 2010, and then finished a two-year postdoctoral training at Shanghai Jiao Tong University.  He currently take part in several national research projects, including those from the National "973" Program and National Natural Science Foundation of China.



    Understanding the neurobiological basis of psychiatric symptoms combining behavioural, genetic approaches and neuroimaging techniques. Identifying biomarkers related to early diagnosis, prognosis and individual treatment in psychiatric diseases. 


1.Yuan A, Li W, Yu T, Zhang C, Wang D, Liu D, Xu Y, Li H, Yu S. SOX10 rs139883 Polymorphism Is Associated with the Age of Onset in Schizophrenia. J Mol Neurosci. 2013; 50(2):333-8.

2.Wei Z, Wang L, Yu T, Wang Y, Sun L, Wang T, Huo R, Li Y, Wu X, Qin S, Xu Y, Feng G, He L, Xing Q. Histamine H4 Receptor (HRH4) Polymorphism: a Potential Predictor of Risperidone Efficacy. Journal of Clinical Psychopharmacology. 2013; 33(2):221-5,

3.Yuan, A, Yi Z, Sun J, Du Y, Yu T, Zhang C, Liu Y, Zhou Y, Liu D, Li H, Xu Y, Cheng Z, Li W, Yu S. Effect of SOX10 gene polymorphism on early onset schizophrenia in Chinese Han population. Neurosci Lett. 2012; 521(2):93-97.

4.Yuan A, Yi ZH, Wang Q, Sun JH, Li ZQ, Yu T, Fan J, Yu SY. ANK3 as a Risk Gene for Schizophrenia: New Data in Han Chinese and Meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2012; 159B(8):997-1005.

5.Huang X, Yu T, Liu B, Li X, Li W, Chen S, Zhao Q, Li X, Yang F, Wang Q, Wang J, Xiao Y, Xu Y, Feng G, Peng Z, He L, He G. Association study of APC polymorphisms with colorectal cancer in Han Chinese. Clinical Biochemistry. 2012; 45(18):1669-72.

6.Yu T, Guo M, Garza J, Sun XL, Lu XY. Cognitive and neural correlates of depression-like behaviour in socially defeated mice: an animal model of depression with cognitive dysfunction. Int J Neuropsychopharmacol. 2011; 14(3):303-17.

7.Min W, Li T, Ma X, Li Z, Yu T, Gao D, Zhang B, Yun Y, Sun X. Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response. Psychopharmacology. 2009; 205(3):409-17.

# Contributed equally to the paper * Corresponding author 

版权所有:上海交通大学Bio-X研究院 沪交ICP备05045号 技术支持:上海屹超