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Electrophysiological Group

 

Shengtian LI

Ph.D., Associate Professor, Principal Investigator

Email: lstian@sjtu.edu.cn

Lab link:lst.sjtu.edu.cn

 

INTRODUCTION:

  By combining in vivo and in vitro electrophysiological, calcium imaging, and animals’ behavioral approaches, the research in Dr. Li's laboratory focuses mainly on the following areas: the cellular and molecular mechanisms of synaptic plasticity and learning & memory, the pathogenesis and early intervention of epilepsy and depression. He has published 23 SCI papers with a combined impact factor of 150 and over 760 citations. His research has been supported by grants from Shanghai Pujiang program, as well as  ‘973 Program Grant’, the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, and Shanghai Committee of Science and Technology. He serves as the Executive Committee Member of the Shanghai Society for Neuroscience and the Shanghai Society of Biophysics.

 

RESEARCH INTERESTS:

  Cellular mechanisms underlying synaptic plasticity and learning & memory, pathogenic mechanisms and early intervention of epilepsy and depression.

 

REPRESENTATIVE PUBLICATIONS:

1.Li ST*, Wang Y, and Matsushita M, (2014) Neurological Disorders Related Neuronal Network Impairment: Function and Mechanism, Neuronal Plasticity, vol 2014, Article ID 945078.

2.Chen LJ, …, Li ST*. (2014) The Effects of Early-life Predator Stress onAnxiety- and Depression-like Behaviors of AdultRats. Neural Plasticity, vol. 2014, Article ID 163908. doi:10.1155/2014/163908.

3.Chao NJ and Li ST*. (2014) Synaptic and Extrasynaptic Glutamate Signaling in Ischemic Stroke. Current Medicinal Chemistry, 21, No. 18. 2043-2064. doi: 10.2174/0929867321666131228204533.

4.Liu DD, Yang Q, Li ST*. (2013) Activation of Extrasynaptic NMDA Receptors induces LTD in Rat Hippocampal CA1 Neurons, Brain Res Bull, 93, 10-16.

5.Li ST*, Ju JG. (2012) Functional Roles of Synaptic and Extrasynaptic NMDA Receptors in Physiological and Pathological Neuronal Activities, Current Drug Targets, 13:207-221.

6.Lin QS, …, Li ST*. (2011) Hippocampal Endocannabinoids Play an Important Role in Induction of Long-term Potentiation and Regulation of Contextual Fear Memory Formation, Brain Res Bull, 86:139-145.

7.Yang Q, …, Li ST*. (2011)  Hippocampal Synaptic Metaplasticity Requires the Activation of NR2B-containing NMDA Receptors. Brain Res Bull, 84:137-143.

8.Ju JG, Li ST*. (2011) Changes of Synaptic- and Extrasynaptic NMDA Receptor-mediated Currents in Adult Mouse Epileptogenesis, Neural Regen Res, 6(2):118-124.

9.Zhang Y, …, Li ST*, Ju G. (2010) Time-dependent Changes of Learning Ability and Induction of Long-term Potentiation in Lithium-pilocarpine-induced Epileptic Mouse Model, Epilepsy Behav, 17, 448-454.

# Contributed equally to the paper * Corresponding author

 

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