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High-through Research Group


Guang HE

Ph. D., Research Professor, Principal Investigator
Email: heguang@sjtu.edu.cn



       Dr. He was awarded “Rising-Star” by the Science and Technology Commission of Shanghai Municipality in 2008. Now Dr. He undertakes the bilingual education of “Medical Genetics” for undergraduate students. Her research works have been sponsored by the 973 Program, NSFC and Shanghai Rising-Star Program.


        Identification of candidate genes for bipolar and other mental disorders. Decoding the century-old mystery of the decreasing incidence of colorectal cancer in schizophrenia patients. To investigate the molecular mechanism of prenatal malnutrition or malnutrition increases the risk of schizophrenia with the rat model.


1. Wang Y, Zhang J, Liu B, Shao L, Wei Z, Li X, Ji J, Yang F, Wang T, Liu J, Wan C, Li B, Xu Y, Feng G, He L*, He G*. Genetic polymorphisms in the SCN8A gene are associated with suicidal behavior in psychiatric disorders in the Chinese population. World J Biol Psychiatry. 2010;11(8):956-63.
2. HTR2C promoter polymorphisms are associated with risperidone efficacy in Chinese female patients.Liu BC, Zhang J, Wang L, Li XW, Wang Y, Wei ZY, Ji J, Yang FP, Wan CL, Xu YF, Feng GY, He L*, He G*. Pharmacogenomics. 2010;11(5):685-92.
3. Shi YY*, He G*, Zhang Z, Tang W, Zhang J Jr, Zhao Q, Zhang J Sr, Li XW, Xi ZR, Fang C, Zhao XZ, Feng GY, He L*. A study of rare structural variants in schizophrenia patients and normal controls from Chinese Han population. Mol Psychiatry. 2008 Oct;13(10):911-3.
4. Zhang J, Shen Y, He G*, Li X, Meng J, Guo S, Li H, Gu N, Feng G, He L*. Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32(2): 467-71.
5. He G#, Liu X#, Qin W, Chen Q, Wang X, Yang Y, Zhou J, Xu Y, Gu N, Feng G, Sang H, Wang P, He L*. MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese. Mol Psychiatry. 2006; 11(8):748-51.
6. Chen Q, He G, Qin W, Chen QY, Zhao XZ, Duan SW, Liu XM, Feng GY, Xu YF, St Clair D, Li M, Wang JH, Xing YL, Shi JG, He L*. Family-based association study of synapsin II and schizophrenia. Am J Hum Genet. 2004; 75(5):873-7.

# Contributed equally to the paper * Corresponding author



Xingwang LI


Ph. D., Research Professor, Master Mentor

Email: xwli@sjtu.edu.cn


       Dr. Li is the deputy group leader of genetic resources center in Bio-X institutes. His research works have been sponsored by 863 Program and other joint research projects. Dr. Li participated in the research on psychiatric disorder and many other complex human genetic diseases and has published over 40 papers as first author or co-author.



       Identification of candidate genes of psychiatric disorders or other complex human genetic diseases.



1.Li X#, Wang Q#, He K, Li Z, Chen J, Li W, Wen Z, Shen J, Qiang Y, Ji J, Feng G, He G, Lin H, Wang Y, Shi Y. Common variants in the CDH7 gene are associated with major depressive disorder in the Han Chinese population. Behav Genet. 2014 Mar;44(2):97-101.

2.Xing-wangLi#, Bao-cheng Liu#, Yang Wang, Qing-zhu Zhao, Qi shen, Tao Yu, Shi-qing Chen, Feng-ping Yang, Wei-dongLi, Ling-han Gao, Yi-feng Xu, Guo-yin Feng, Lin He, Guang He. Association study on the DLG4 gene and schizophrenia in the Chinese Han population. Psychiatric Genetics. Psychiatr Genet. 2013 Dec;23(6):247-50.

3.Xing-wang Li#, Bao-cheng Liu#, Yang Wang, Qing-zhu Zhao, Qi shena, Shi-qing Chen, Jue Ji, Feng-ping Yang, Ling-han Gao, Yifeng Xu, Guo-yin Feng, Lin He, Guang He. NAPG may not a common risk gene shared by Bipolar Disorder and Schizophrenia in Chinese population. Psychiatric Genetics. 2012 Apr;22(2):107-8.

4.Xingwang Li#, Jing Zhang#, YangWang, Jue Ji, Fengping Yang, ChunlingWan, PengWang, Guoyin Feng, Klaus Lindpaintner, Lin He, Guang He. Association study on the NAPG gene and bipolar disorder in the Chinese Han population  Neuroscience Letters Neurosci Lett. 2009 Jul 3;457(3):159-62.

5.Zhang J#, Li X#, Wang Y, Ji J, Yang F, Feng G, Wan P, Lindpaintner K, He L, He G. Association study on the mitochondrial gene NDUFV2 and bipolar disorder in the Chinese Han population.  J Neural Transm. 2009 Mar;116(3):357-61.

# Contributed equally to the paper * Corresponding author

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