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Skeletal Development and Related Diseases


Xizhi GUO


Ph.D., Professor, Principal Investigator

Email: xzguo2005@aliyun.com



  Dr Guo is a winner of Young Investigator of ASBMR (2005), Fellow Award for Research Excellence in NIH (2005), Shanghai Pujiang Talent (2008) and Chief Scientist of the project of State Key Development Program for Basic Research of China with theme of “The molecular mechanisms underlying skeletal development and disorders” (Grant No. 2007CB947300).



   The mechanisms underlying skeletal development; Developing therapeutic strategies for bone diseases including osteoporosis and osteoarthritis; the role of miRNA in osteogenesis; the therapeutic exploring of mesenchymal stem cell in bone diseases treatment.



1.Haixia Zhao, Wenrong Zhou, Zhengju Yao, Yong Wan, Jingjing Cao, Lingling Zhang, Jianzhi Zhao, Hanjun Li, Rujiang Zhou, Baojie Li, Gang Wei, Zhenlin Zhang, Catherine A. French, Joseph D. Dekker, Yingzi Yang, Simon E. Fisher, Haley O. Tucker, Xizhi Guo* (2015) Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Developmental Biology 398:242-254.

2.Lingling  Zhang; Hanjun Li; Jian  Yu; Jingjing  Cao; Huihui Chen; Haixia  Zhao; Jianzhi  Zhao; Yiyun Yao; Lifang  Wang; Rujiang  Zhou; Zhengju  Yao, Xizhi Guo* (2014) Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Developmental Biology 387: 64–72

3.Xuming Zhu, Sixia Huang, Lingling Zhang, Yumei Wu, Yingwei Chen, Yixin Tao, Yushu Wang, Shigang He, Sanbing Shen, Ji Wu, Baojie Li, Xizhi Guo*, Lin He*, Gang Ma* (2014) Constitutive Activation of Ectodermal β-Catenin Induces Ectopic Outgrowths at Various Positions in Mouse Embryo and Affects Abdominal Ventral Body Wall Closure. Plos One 9(3): e92092

4.Wenrong Zhou, Huang Zhu, Jinazhi Zhao, Hanjun Li, Yong Wan, Jingjing Cao, Haixia Zhao, Jian Yu, Rujiang Zhou, Yiyun Yao, Lingling Zhang, Lifang Wang, Lin He, Gang Ma, Zhengju Yao, Xizhi Guo* (2013) Misexpression of Pknox2 in mouse limb bud mesenchyme perturbs zeugopod development and deltoid crest formation. PLoS One. 8(5):e64237

5.Yong Wan, Cheng Lu, Jingjing Cao, Rujiang Zhou, Yiyun Yao,Jian Yu,Lingling Zhang, Haixia Zhao, Hanjun Li, Jianzhi Zhao, Xuming Zhu, Lin He, Yongzhong Liu, Zhengju Yao, Xiao Yang and Xizhi Guo* (2013) Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells. Bone. 55(1):258-67

6.Cheng Lu, Yong Wan, Jingjing Cao,Xuming Zhu, Jian Yu,Rujiang Zhou, Yiyun Yao, Lingling Zhang, Haixia Zhao, Hanjun Li, Jianzhi Zhao, Lin He, Gang Ma, Zhengju Yao, and Xizhi Guo*(2013) Wnts-mediated reciprocal regulation between cartilage and bone development during endochondral ossification. Bone. 53(2):566-74.

7.Huang Zhu, Jianzhi Zhao, Wenrong Zhou, Hanjun Li, Rujiang Zhou, Lingling Zhang, Haixia Zhao, Jingjing Cao, Xuming Zhu, Hongliang Hu, Gang Ma, Lin He, Zhengju Yao, Libo Yao, Xizhi Guo* (2012) Ndrg2 regulates vertebral specification in differentiating somites. Developmental Biology. 369(2):308-18.

8.Xuming Zhu, Huang Zhu, Lingling Zhang, Sixia Huang, Jingjing Cao, Gang Ma, Guoying Feng, Lin He, Yingzi Yang, Xizhi Guo* (2012) Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis. Developmental Biology. 365(2):328-38.

9.Sixia Huang, Xuming Zhu, Yanfang Liu, Yixin Tao, Guoyin Feng, Lin He, Xizhi Guo*, Gang Ma (2012) Wls Is Expressed in the Epidermis and Regulates Embryonic Hair Follicle Induction in Mice. PLoS One. 7(9):e45904.

10.Yang J, Qin S, Yi C, Ma G, Zhu H, Zhou W, Xiong Y, Zhu X, Wang Y, He L, Guo X*. MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation. FEBS Lett. 2011;585(19):2992-7.

11.Xiao Y, Zhang L, He K, Gao X, Yang L, He L, Ma G, Guo X*. Characterization of a novel missense mutation on murine Pax3 through ENU mutagenesis. J Genet Genomics. 2011; 38(8):333-9.

12.Guo X, Mak KK, Taketo MM, Yang Y*. The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One. 2009; 26;4(6):e6067.

13.Lin C#, Jiang X#, Dai Z, Guo X, Weng T, Wang J, Li Y, Feng G, Gao X*, He L*. Sclerostin Mediates Bone Response to Mechanical Unloading via Antagonizing Wnt/beta-Catenin Signaling. J Bone Miner Res. 2009; 24(10):1651-61.

14.Zhou J, Meng J, Guo S, Gao B, Ma G, Zhu X, Hu J, Xiao Y, Lin C, Wang H, Ding L, Feng G, Guo X, He L*. IHH and FGF8 coregulate elongation of digit primordia. Biochem Biophys Res Commun. 2007; 363(3):513-8.

15.Day TF#, Guo X#, Garrett-Beal L, Yang Y*. Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis. Dev Cell. 2005; 8 (5): 739-750.

16.Guo X#, Day TF#, Jiang X, Garrett-Beal L, Topol L, Yang Y*. Wnt/-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev. 2004; 18:2404-2417.

# Contributed equally to the paper * Corresponding author


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